About me

Dr Dipa Jayaseelan

MBBS (Hons) , MA (Cantab) , PhD, MRCP (UK)

Dr Dipa Jayaseelan

Current Practice

Dr Jayaseelan sees a wide variety of patients with both routine and complex neurological conditions and has a specialist interest in neuromuscular diseases.

She sees private patients in both London and Hertfordshire including at Cleveland Clinic London and Queen Square Private Consulting rooms.

Dr Jayaseelan also runs a large NHS practice at both the internationally renowned National Hospital for Neurology and Neurosurgery in London and West Hertfordshire NHS Trust where she sees a mixture of general neurology patients, acute inpatient neurology and specialist neuromuscular patients. She co-leads the NHS England Highly Specialised Service in Muscle Channelopathies (channelopathy.nhs.uk). She also has an honorary contract at Great Ormond Street Hospital where she consults on children with channelopathies and adolescents with inherited neuromuscular disorders. She runs specialist clinics in muscle channelopathies, Kennedy’s disease and neuromuscular transition, seeing patients with a wide variety of inherited muscle conditions.

Medical Training

Dr Jayaseelan undertook her undergraduate medical training at the University of Cambridge where she was awarded a Scholarship and completed a Bachelors in Neurosciences. She went on to graduate in Medicine and Surgery with a Distinction in Clinical Practice from University College London (UCL) in 2005. She undertook her medical and neurological training at major London teaching hospitals including the National Hospital for Neurology and Neurosurgery, Hammersmith Hospital and the Royal Free Hospital.

research lab microscope

Research

Dr Jayaseelan has a keen research interest in neurological channelopathies, having been awarded a PhD in Neuromuscular diseases at the UCL Institute of Neurology. She is currently an Honorary Lecturer at UCL where she is actively researching muscle channelopathies, Kennedy’s disease and other genetic neuromuscular conditions. She is Principal Investigator and Co-investigator for a number of research studies at UCL. She has published over 30 peer-reviewed papers and book chapters in neuromuscular diseases and neurological complications of coronavirus.

Teaching

Dr Jayaseelan plays a number of key teaching roles including acting as an examiner for the Royal College of Physicians’ Neurology question writing group. She is a lecturer on the PassPACES postgraduate course and a MSc lecturer for the UCL Clinical Neurosciences MSc course. She also acts as an educational and clinical supervisor for junior doctors and a PhD supervisor for PhD students.

Prizes & Awards

STEP finalist award

  • Charles Symonds Prize (2018) – Association of British Neurologists. Best Quality and Training Presentation by a junior neurologist

  • Association of British Neurologists Bursary (2018)

  • UK Neuromuscular Translational Research Conference Presentation prize (2012)

  • MRC Clinical Research Training Fellowship (2010 – 2014)

  • NIH funded CINCH Trainee Fellowship (2009-2010)

  • Distinction in Clinical Practice - University of London (2005)- for MBBS exams

  • Shell Technology Most Enterprising Student (STEP) Award (2001) - UK finalist, London and Greater London winner

  • Scholarship at Christ’s College, Cambridge University (2000)

  • Nuffield Science Bursary (1998/99)

Publications

Dr Dipa L Jayaseelan (née Raja Rayan)

 
Research papers 
  • Statland, J. M., Bundy, B. N., Wang, Y., Rayan, D. R., et al. (2012). Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial. JAMA : the journal of the American Medical Association, 308(13), 1357–65
  • Statland, J. M., Bundy, B. N., Wang, Y., Trivedi, J. R., Raja Rayan, D., et al (2012). A quantitative measure of handgrip myotonia in non-dystrophic myotonia.. Muscle Nerve, 46(4), 482-489.
  • Raja Rayan DL, Haworth A, Sud R, et al. A new explanation for recessive myotonia congenita: Exon deletions and duplications in CLCN1.Neurology 78(24):1953-1958 12 Jun 2012
  • Tan SV, Z'graggen WJ, Boërio D, Rayan DL, et al. (2012) Membrane dysfunction in Andersen-Tawil syndrome assessed by velocity recovery cycles. Muscle Nerve 46(2):193-203
  • A.Haworth, L.Bertram, P.Carrera, et al. Call for participation in the neurogenetics consortium within the Human Variome Project. Neurogentics 2011 Jun 1;1-5.
  • Raja Rayan, D.L & Hanna, M.G Skeletal Muscle Channelopathies: Non-Dystrophic Myotonias and Periodic Paralysis. Current Opinion in Neurology 2010 Oct;23(5):466-76.
  • Raja Rayan, Dipa L and Hanna, Michael G (October 2010) Ion Channels and Human Disorders. In: Encyclopedia Of Life Sciences. 2010, John Wiley & Sons, Ltd: Chichester http://www.els.net/ [DOI: 10.1002/9780470015902.a0005166.pub2]
  • Raja Rayan, D. L., & Hanna, M. G. (2020). Managing pregnancy and anaesthetics in patients with skeletal muscle channelopathies. Neuromuscular disorders : NMD, 30(7), 539–545. https://doi.org/10.1016/j.nmd.2020.05.007
  • Suetterlin, K.J, Raja Rayan, D., Matthews, E. & Hanna, M.G. (2020) Mexiletine (NaMuscla) for the treatment of myotonia in non-dystrophic myotonic disorders, Expert Opinion on Orphan Drugs, 8:2-3, 43-49, DOI: 10.1080/21678707.2020.1739519
  • Paterson, R. W., Brown, R. L., Benjamin, L., Nortley, R., Wiethoff, S., Bharucha, T., Jayaseelan, D. L., et al (2020). The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. https://doi.org/10.1093/brain/awaa240
  • Keddie, S., Pakpoor, J., Mousele, C., et al (2020). Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barre syndrome. (in press) Brain
  • Raja Rayan, D.L. and Hanna, M.G. (January 2018) Ion Channels and Human Disorders. In: Encyclopedia Of Life Sciences DOI: 10.1002/9780470015902.a0005166.pub3
  • Matthews E, Neuwirth C, Jaffer F, Scalco RS, Fialho D, Parton M, Raja Rayan D, et al. (2018) Atypical periodic paralysis and myalgia: A novel phenotype. Neurology, 90 (5), pp. e412-e418
  • Neuromuscular Disease: Case Studies from Queen Square - Manji H., Turner C., Evans M.R.B. 1st ed. (2017) Springer London Ltd Chapters 32, 33,36,37 & 45. Book.
  • Challenging Concepts in Neurology (2016) Chinthapalli Krishna, Magdalinou Nadia, Wood Nicholas – Chapter 17:Myotonic Dystrophy. D Raja Rayan. Oxford University Press. Book.
  • Rayan, D., Horga, A., Matthews, E., Sud, R., McCall, S., Hanna, M. (2015). Paramyotonia Congenita & Sodium Channel Myotonia: Are they distinct diseases?. JNNP. 86. e4.13-e4. 10.1136/jnnp-2015-312379.11.
  • Corrochano, S., Männikkö, R., Joyce, P. I., McGoldrick, P., Wettstein, J., Lassi, G, Raja Raja Rayan D.L et al (2014). Novel mutations in human and mouse SCN4A implicate AMPK in myotonia and periodic paralysis. Brain, 137(Pt 12), 3171-3185. doi:10.1093/brain/awu292
  • Tan, S. V., Z'Graggen, W. J., Boërio, D., Rayan, D. R., et al (2014). Chloride channels in myotonia congenita assessed by velocity recovery cycles.. Muscle Nerve, 49(6), 845-857. doi:10.1002/mus.24069
  • Thor, M.G., Durran, S., Matthews, E., Rayan, D., Sweeney, M., Hanna, M.G., Mannikko, R. (2014). P44 Mutations of the same S4 arginine residue in NaV1.4 can result in either myotonia or hypokalemic periodic paralysis. Neuromuscular Disorders. 24. S18-S19. 10.1016/S0960-8966(14)70060-4.
  • Morrow, J. M., Matthews, E., Raja Rayan, D. L., et al (2013). Muscle MRI reveals distinct abnormalities in genetically proven non-dystrophic myotonias. Neuromuscular Disorders, 23(8), 637-646. doi:10.1016/j.nmd.2013.05.001
  • Horga, A., Rayan, D. L. R., Matthews, E., et al (2013). Prevalence study of genetically defined skeletal muscle channelopathies in England. Neurology, 80(16), 1472-1475. doi:10.1212/WNL.0b013e31828cf8d0
  • Hehir, M. K., Logigian, E., Raja Rayan, D. L., & Ciafaloni, E. (2013). Double trouble in a patient with myotonia.. BMJ case reports, 2013.
  • Tan, S. V., Z'graggen, W. J., Boërio, D., Rayan, D. R., et al (2013). Chloride channels in myotonia congenita assessed by velocity recovery cycles.. Muscle Nerve. doi:10.1002/mus.24069
  • Trivedi, J. R., Bundy, B., Statland, J., Salajegheh, M., Rayan, D. R., et al (2013). Non-dystrophic myotonia: prospective study of objective and patient reported outcomes.. Brain, 136(Pt 7), 2189-2200. doi:10.1093/brain/awt133